Phylogenetic studies of transmission dynamics in generalized HIV epidemics: An essential tool where the burden is greatest?. J Acquir Immune Defic Syndr., in press: (2014).

Publication Latest Publications

Title: Phylogenetic studies of transmission dynamics in generalized HIV epidemics: An essential tool where the burden is greatest?
Authors: Dennis AM, Herbeck JT, Brown AL, Kellam P, de Oliveira T, Pillay D, Fraser C, Cohen MS.
Journal: J Acquir Immune Defic Syndr.,in press: (2014)

Journal Impact Factor (I.F.): 4.262
Number of citations (Google Scholar): 15

Abstract

Efficient and effective HIV prevention measures for generalized epidemics in sub-Saharan Africa have not yet been validated at the population-level. Design and impact evaluation of such measures requires fine-scale understanding of local HIV transmission dynamics.

The novel tools of HIV phylogenetics and molecular epidemiology may elucidate these transmission dynamics. Such methods have been incorporated into studies of concentrated HIV epidemics to identify proximate and determinant traits associated with ongoing transmission. However, applying similar phylogenetic analyses to generalized epidemics, including the design and evaluation of prevention trials, presents additional challenges.

Here we review the scope of these methods and present examples of their use in concentrated epidemics in the context of prevention. Next, we describe the current uses for phylogenetics in generalized epidemics, and discuss their promise for elucidating transmission patterns and informing prevention trials. Finally, we review logistic and technical challenges inherent to large-scale molecular epidemiological studies of generalized epidemics, and suggest potential solutions.

Download: Full text paper

Citation: Dennis AM, Herbeck JT, Brown AL, Kellam P, de Oliveira T, Pillay D, Fraser C, Cohen MS. Phylogenetic studies of transmission dynamics in generalized HIV epidemics: An essential tool where the burden is greatest? J Acquir Immune Defic Syndr.,in press: (2014).


Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
Journal: Science (2018)

Effect of population viral load on prospective HIV incidence in a hyperendemic rural African community
Journal: Science Translational Medicine (2017)

Highlights of the second ISCB Student Council Symposium in Africa, 2017
Journal: F1000 Research (2017)
All publications...


Page design updated by Tulio de Oliveira, 2013