Title: Phylogenetic studies of transmission dynamics in generalized HIV epidemics: An essential tool where
the burden is greatest?
Authors: Dennis AM, Herbeck JT, Brown AL, Kellam P, de Oliveira T, Pillay D, Fraser C, Cohen MS.
Journal: J Acquir Immune Defic Syndr.,in press: (2014)
Journal Impact Factor (I.F.): 4.262
Number of citations (Google Scholar): 15
Efficient and effective HIV prevention measures for generalized epidemics in sub-Saharan Africa have not yet
been validated at the population-level. Design and impact evaluation of such measures requires fine-scale
understanding of local HIV transmission dynamics.
The novel tools of HIV phylogenetics and molecular
epidemiology may elucidate these transmission dynamics. Such methods have been incorporated into studies
of concentrated HIV epidemics to identify proximate and determinant traits associated with ongoing
transmission. However, applying similar phylogenetic analyses to generalized epidemics, including the design
and evaluation of prevention trials, presents additional challenges.
Here we review the scope of these methods
and present examples of their use in concentrated epidemics in the context of prevention. Next, we describe
the current uses for phylogenetics in generalized epidemics, and discuss their promise for elucidating
transmission patterns and informing prevention trials. Finally, we review logistic and technical challenges
inherent to large-scale molecular epidemiological studies of generalized epidemics, and suggest potential
Citation: Dennis AM, Herbeck JT, Brown AL, Kellam P, de Oliveira T, Pillay D, Fraser C, Cohen MS. Phylogenetic studies of transmission dynamics in generalized HIV epidemics: An essential tool where
the burden is greatest? J Acquir Immune Defic Syndr.,in press: (2014).